Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance

Author:

Park Eugene1ORCID,Chen Jingyu1ORCID,Moore Andrew1ORCID,Mangolini Maurizio1ORCID,Santoro Antonella1ORCID,Boyd Joseph R.2ORCID,Schjerven Hilde34ORCID,Ecker Veronika56,Buchner Maike56,Williamson James C.7,Lehner Paul J.7ORCID,Gasparoli Luca8ORCID,Williams Owen8,Bloehdorn Johannes9ORCID,Stilgenbauer Stephan9,Leitges Michael10ORCID,Egle Alexander111213ORCID,Schmidt-Supprian Marc1415,Frietze Seth16ORCID,Ringshausen Ingo1ORCID

Affiliation:

1. Wellcome Trust/MRC Cambridge Stem Cell Institute and Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AH, UK.

2. Department of Biochemistry and University of Vermont Cancer Center, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA.

3. Department of Laboratory Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA.

4. KG Jebsen Centre for B cell Malignancies, IMM, OUH, 0424 Oslo, Norway.

5. Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.

6. TranslaTUM, Center for Translational Cancer Research, Technische Universität München, 81675 Munich, Germany.

7. Cambridge Institute for Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK.

8. University College London (UCL) GOS-ICH, London WC1N 1EH, UK.

9. Department of Internal Medicine III, University of Ulm, 89081 Ulm, Germany.

10. Faculty of Medicine, Craig L. Dobbin Genetics Research Centre, Memorial University of Newfoundland, St. John’s, Newfoundland A1B 3V6, Canada.

11. IIIrd Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases and Rheumatology, Oncologic Center, Paracelsus Medical University, Cancer Cluster Salzburg, 5020 Salzburg, Austria.

12. Salzburg Cancer Research Institute (SCRI) with Laboratory of Immunological and Molecular Cancer Research (LIMCR), 5020 Salzburg, Austria.

13. Cancer Cluster Salzburg, 5020 Salzburg, Austria.

14. German Cancer Consortium, DKFZ, 69120 Heidelberg, Germany.

15. Institute of Experimental Hematology, School of Medicine, Technical University Munich, 81675 Munich, Germany.

16. Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT 05405, USA.

Abstract

Inhibition of stromal cell PKC-β mitigates environment-mediated drug resistance in B cell malignancies.

Funder

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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