Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Published:2020-08-05 Issue:555 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lupo Barbara¹²^ORCID,Sassi Francesco²,Pinnelli Marika¹²^ORCID,Galimi Francesco¹²^ORCID,Zanella Eugenia R.²^ORCID,Vurchio Valentina¹²^ORCID,Migliardi Giorgia¹²^ORCID,Gagliardi Paolo Armando¹²^ORCID,Puliafito Alberto¹²^ORCID,Manganaro Daria³,Luraghi Paolo²,Kragh Michael⁴,Pedersen Mikkel W.⁴^ORCID,Horak Ivan D.⁴,Boccaccio Carla¹²^ORCID,Medico Enzo¹²^ORCID,Primo Luca¹²^ORCID,Nichol Daniel⁵,Spiteri Inmaculada⁵^ORCID,Heide Timon⁵^ORCID,Vatsiou Alexandra⁵,Graham Trevor A.⁶^ORCID,Élez Elena⁷,Argiles Guillem⁷,Nuciforo Paolo⁷^ORCID,Sottoriva Andrea⁵^ORCID,Dienstmann Rodrigo⁷,Pasini Diego³⁸^ORCID,Grassi Elena²^ORCID,Isella Claudio¹²,Bertotti Andrea¹²^ORCID,Trusolino Livio¹²^ORCID

Affiliation:

1. Department of Oncology, University of Torino, 10060 Candiolo, Torino, Italy.

2. Candiolo Cancer Institute—FPO IRCCS, 10060 Candiolo, Torino, Italy.

3. European Institute of Oncology, 20139 Milano, Italy.

4. Symphogen A/S, 2750 Ballerup, Denmark.

5. The Institute of Cancer Research, London SW7 3RP, UK.

6. Centre for Genomics and Computational Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.

7. Vall d’Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain.

8. Department of Health Sciences, University of Milano, 20142 Milano, Italy.

Abstract

Drug tolerance in EGFR-inhibited mCRC involves secretory pseudodifferentiation and rewiring of oncogenic dependencies.

Funder

European Research Council

Associazione Italiana per la Ricerca sul Cancro

Fondazione Piemontese per la Ricerca sul Cancro-ONLUS

H2020 INFRAIA

Eranet Transcan

European Union H2020 Programme

Publisher