Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

Author:

Zhou Zhenqi1ORCID,Moore Timothy M.1,Drew Brian G.1,Ribas Vicent1ORCID,Wanagat Jonathan2,Civelek Mete3ORCID,Segawa Mayuko1ORCID,Wolf Dane M.1ORCID,Norheim Frode3,Seldin Marcus M.3ORCID,Strumwasser Alexander R.1,Whitney Kate A.1,Lester Ellen1ORCID,Reddish Britany R.1ORCID,Vergnes Laurent3,Reue Karen3,Rajbhandari Prashant4,Tontonoz Peter4,Lee Jason5ORCID,Mahata Sushil K.67ORCID,Hewitt Sylvia C.8ORCID,Shirihai Orian1,Gastonbury Craig9ORCID,Small Kerrin S.9ORCID,Laakso Markku10,Jensen Jorgen11ORCID,Lee Sindre12ORCID,Drevon Christian A.12ORCID,Korach Kenneth S.8ORCID,Lusis Aldons J.3,Hevener Andrea L.113ORCID

Affiliation:

1. Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, University of California, Los Angeles, CA 90095, USA.

2. Division of Geriatrics, Department of Medicine, University of California, Los Angeles, CA 90095, USA.

3. Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

4. Department of Pathology and Laboratory Medicine and the Howard Hughes Research Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

5. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

6. VA San Diego Healthcare System, San Diego, CA 92161, USA.

7. Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

8. Receptor Biology Section, NIEHS, NIH, Research Triangle Park, NC 27709, USA.

9. Department of Twin Research and Genetic Epidemiology, King's College London, London SE17EH, UK.

10. Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.

11. Department of Physical Performance, Norwegian School of Sport Science, Oslo 0806, Norway.

12. University Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo 0316, Norway.

13. Iris Cantor-UCLA Women’s Health Research Center, Los Angeles, CA 90095, USA.

Abstract

ERα gene expression is heritable in humans and prevents obesity in mice by improving mitochondrial function via adipocyte Polg1 expression.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

University of Southern California

American College of Sports Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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