Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis-Reference-Cited by-同舟云学术

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Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis

Published:2019-11-20 Issue:519 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Amorim Camila Farias¹^ORCID,Novais Fernanda O.¹^ORCID,Nguyen Ba T.¹^ORCID,Misic Ana M.¹^ORCID,Carvalho Lucas P.²³,Carvalho Edgar M.²³,Beiting Daniel P.¹^ORCID,Scott Phillip¹^ORCID

Affiliation:

1. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, PA 19104-4539, USA.

2. Serviço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Bahia 40110-060, Brazil.

3. Laboratório de Pesquisas Clínicas do Instituto de Pesquisas Gonçalo Moniz, Fiocruz Bahia, 40296-710, Brazil.

Abstract

Variability in immune gene expression between patient lesions predicts treatment outcome in cutaneous leishmaniasis.

Funder

International Collaborations in Infectious Disease Research

Tropical Medicine Research Center

Center for Host-Microbial Interactions

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference56 articles.

1. Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy

2. The Elderly Respond to Antimony Therapy for Cutaneous Leishmaniasis Similarly to Young Patients but Have Severe Adverse Reactions

3. Drug resistance and treatment failure in leishmaniasis: A 21st century challenge

4. A Low-Dose Antimony Treatment in 159 Patients with American Cutaneous Leishmaniasis: Extensive Follow-up Studies (Up to 10 Years)

5. Influence ofLeishmania (Viannia)Species on the Response to Antimonial Treatment in Patients with American Tegumentary Leishmaniasis

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3. Neutrophil-mediated hypoxia drives pathogenic CD8+ T cell responses in cutaneous leishmaniasis;Journal of Clinical Investigation;2024-06-04

4. CCR5 promotes the migration of pathological CD8+ T cells to the leishmanial lesions;PLOS Pathogens;2024-05-06

5. NKG2C+CD57+ natural killer cells with senescent features are induced during cutaneous leishmaniasis and accumulate in patients with lesional healing impairment;Clinical and Experimental Immunology;2024-05-03

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