An innate-like Vδ1 + γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer-Reference-Cited by-同舟云学术

An innate-like Vδ1 + γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

Published:2019-10-09 Issue:513 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wu Yin¹²³⁴^ORCID,Kyle-Cezar Fernanda¹²^ORCID,Woolf Richard T.¹⁵^ORCID,Naceur-Lombardelli Cristina⁶^ORCID,Owen Julie⁶^ORCID,Biswas Dhruva⁴⁷^ORCID,Lorenc Anna¹^ORCID,Vantourout Pierre¹²^ORCID,Gazinska Patrycja³⁸,Grigoriadis Anita³^ORCID,Tutt Andrew³⁸^ORCID,Hayday Adrian¹²^ORCID

Affiliation:

1. Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King’s College London, London SE1 9RT, UK.

2. Immunosurveillance Laboratory, Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

3. Breast Cancer Now Research Unit, Innovation Hub, Cancer Centre at Guy’s Hospital, Faculty of Life Sciences and Medicine, King’s College London, London SE1 9RT, UK.

4. Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, University College London, London WC1E 6DD, UK.

5. St John's Institute of Dermatology, King's College London, London SE1 9RT, UK.

6. KHP Cancer Biobank, Innovation Hub, Cancer Centre at Guy’s Hospital, Faculty of Life Sciences and Medicine, King’s College London, London SE1 9RT, UK.

7. Bill Lyons Informatics Centre, University College London Cancer Institute, University College London, London WC1E 6DD, UK.

8. Breast Cancer Now Research Centre, Institute of Cancer Research, London SW3 6JB, UK.

Abstract

An innate-like γδ T cell compartment in healthy human breast is described and shown to correlate with remission in triple-negative breast cancer.

Funder

Breast Cancer Now

Wellcome

Medical Research Council

National Institute for Health Research

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference88 articles.

1. Structure, organization, and somatic rearrangement of T cell gamma genes

2. Identification of a putative second T-cell receptor

3. Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

4. Regulation of Cutaneous Malignancy by γδ T Cells

5. Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis

Cited by 103 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient;Nature Communications;2024-02-06

2. Gamma/delta T cells as cellular vehicles for anti-tumor immunity;Frontiers in Immunology;2024-01-11

3. PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy;Nature Cancer;2024-01-03

4. Extracellular vesicles remodel tumor environment for cancer immunotherapy;Molecular Cancer;2023-12-13

5. γδ T cells: origin and fate, subsets, diseases and immunotherapy;Signal Transduction and Targeted Therapy;2023-11-22