Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents

Author:

Antounians Lina12ORCID,Catania Vincenzo D.12,Montalva Louise12,Liu Benjamin D.12ORCID,Hou Huayun34ORCID,Chan Cadia34ORCID,Matei Andreea C.12,Tzanetakis Areti12,Li Bo25ORCID,Figueira Rebeca L.6,da Costa Karina M.6,Wong Amy P.1,Mitchell Robert7,David Anna L.89ORCID,Patel Ketan710ORCID,De Coppi Paolo1112ORCID,Sbragia Lourenço6,Wilson Michael D.34ORCID,Rossant Janet14ORCID,Zani Augusto1213ORCID

Affiliation:

1. Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, M5G 0A4, Canada.

2. Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, M5G 1X8, Canada.

3. Genetics and Genome Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, M5G 0A4, Canada.

4. Department of Molecular Genetics, University of Toronto, Toronto, M5S 1A8, Canada.

5. Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, M5G 0A4, Canada.

6. Laboratory of Experimental Fetal and Neonatal Surgery, Division of Pediatric Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paolo, 14049-900, Brazil.

7. School of Biological Sciences, University of Reading, Reading RG6 6AS, UK.

8. Institute for Women’s Health, University College London, London WC1E 6HU, UK.

9. NIHR University College London Hospitals Biomedical Research Centre, London W1T 7HA, UK.

10. FRIAS Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg 79104, Germany.

11. Stem Cell and Regenerative Medicine Section, Great Ormond Street Institute of Child Health, University College of London, London WC1N 1EH, UK.

12. NIHR Biomedical Research Centre and Specialist Neonatal and Paediatric Unit, Great Ormond Street Hospital, London WC1N 1EH, UK.

13. Department of Surgery, University of Toronto, Toronto, M5T 1P5, Canada.

Abstract

Administration of extracellular vesicles derived from amniotic fluid stem cells regenerates underdeveloped fetal lungs in rodents.

Funder

Centre for Applied Genomics

Hospital for Sick Children

Foundation for the Support of Teaching, Research and Service of the University Hospital

Coordination for the Improvement of Higher Education Personne

National Council for Scientific and Technological Development

CIHR-SickKids Foundation

SickKids Restracomp Fellowship

NSERC

Ontario Ministry of Research and Innovation

Tier 2 Canada Research Chair

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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