Cyclin-dependent–like kinase 5 is required for pain signaling in human sensory neurons and mouse models-Reference-Cited by-同舟云学术

Cyclin-dependent–like kinase 5 is required for pain signaling in human sensory neurons and mouse models

Published:2020-07-08 Issue:551 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

La Montanara Paolo¹^ORCID,Hervera Arnau¹²³⁴^ORCID,Baltussen Lucas L.⁵^ORCID,Hutson Thomas H.¹^ORCID,Palmisano Ilaria¹^ORCID,De Virgiliis Francesco¹^ORCID,Kong Guiping¹^ORCID,Chadwick Jessica¹^ORCID,Gao Yunan⁶^ORCID,Bartus Katalin⁷^ORCID,Majid Qasim A.⁸,Gorgoraptis Nikos¹^ORCID,Wong Kingsley⁹,Downs Jenny⁹^ORCID,Pizzorusso Tommaso¹⁰¹¹^ORCID,Ultanir Sila K.⁶^ORCID,Leonard Helen⁹^ORCID,Yu Hongwei¹²,Millar David S.¹³^ORCID,Istvan Nagy¹⁴^ORCID,Mazarakis Nicholas D.⁶^ORCID,Di Giovanni Simone¹^ORCID

Affiliation:

1. Department of Brain Sciences, Division of Neuroscience, Imperial College London, London W12 0NN, UK.

2. Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.

3. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain.

4. Department of Cell Biology, Physiology and Immunology, Faculty of Biology & Institute of Neuroscience, Universitat de Barcelona, 08028 Barcelona, Spain.

5. Kinases and Brain Development Laboratory, Francis Crick Institute, London NW1 1AT, UK.

6. Gene Therapy, Centre for Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Department of Medicine, Imperial College London, London W12 0NN, UK.

7. Wolfson Centre for Age-Related Diseases, King’s College London, Guy’s Campus, London Bridge, London SE1 1UL, UK.

8. National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.

9. Telethon Kids Institute, University of Western Australia, Perth, WA 6009, Australia.

10. Institute of Neuroscience, National Research Council (CNR), I-56124 Pisa, Italy.

11. Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, I-50135 Florence, Italy.

12. Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

13. Institute of Cancer and Genetics, Cardiff University, Cardiff F14 4ED, UK.

14. Nociception, Section of Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK.

Abstract

CDKL5 controls nociception in human neurons and murine models of CDKL5 deficiency disorder via CaMKII-dependent mechanisms.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference65 articles.

1. CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasms

2. What We Know and Would Like to Know about CDKL5 and Its Involvement in Epileptic Encephalopathy

3. Molecular and genetic insights into an infantile epileptic encephalopathy – CDKL5 disorder

4. Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

5. Synaptic Synthesis, Dephosphorylation, and Degradation

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