Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation

Author:

Ordonez Alvaro A.123ORCID,Sellmyer Mark A.45ORCID,Gowrishankar Gayatri6ORCID,Ruiz-Bedoya Camilo A.123ORCID,Tucker Elizabeth W.1378ORCID,Palestro Christopher J.9ORCID,Hammoud Dima A.10,Jain Sanjay K.12311ORCID

Affiliation:

1. Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

3. Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

4. Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA 94305, USA.

7. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

8. Division of Pediatric Critical Care, Johns Hopkins All Children’s Hospital, St. Petersburg, FL 33701, USA.

9. Department of Radiology, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA.

10. Center for Infectious Disease Imaging, Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD 20814, USA.

11. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Abstract

Molecular imaging could fulfill unmet clinical needs for diagnosing and monitoring bacterial infections, if translational barriers are addressed.

Funder

U.S. Department of Defense

National Heart, Lung, and Blood Institute

National Institute of Biomedical Imaging and Bioengineering

Burroughs Wellcome Fund

NIH Office of the Director / National Institute Of Dental & Craniofacial Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference40 articles.

1. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

2. After 2015: infectious diseases in a new era of health and development

3. World Health Organization Global Tuberculosis Report 2018 (World Health Organization 2018); www.who.int/gho/tb/en/.

4. Multistate Point-Prevalence Survey of Health Care–Associated Infections

5. Centers for Disease Control and Prevention The Direct Medical Costs of Healthcare-Associated Infections in U.S. Hospitals and the Benefits of Prevention (Centers for Disease Control and Prevention 2009); www.cdc.gov/hai/pdfs/hai/scott_costpaper.pdf.

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