Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8 + T cells

Author:

Nguyen Son1ORCID,Deleage Claire2ORCID,Darko Samuel3ORCID,Ransier Amy3,Truong Duc P.4ORCID,Agarwal Divyansh5ORCID,Japp Alberto Sada1ORCID,Wu Vincent H.1ORCID,Kuri-Cervantes Leticia1ORCID,Abdel-Mohsen Mohamed6ORCID,Del Rio Estrada Perla M.7ORCID,Ablanedo-Terrazas Yuria7,Gostick Emma8ORCID,Hoxie James A.9ORCID,Zhang Nancy R.5ORCID,Naji Ali10ORCID,Reyes-Terán Gustavo7ORCID,Estes Jacob D.1112ORCID,Price David A.8ORCID,Douek Daniel C.3,Deeks Steven G.13ORCID,Buggert Marcus14ORCID,Betts Michael R.1ORCID

Affiliation:

1. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.

3. Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4. Department of Mathematics, Southern Methodist University, Dallas, TX 75205, USA.

5. Department of Statistics, University of Pennsylvania, Philadelphia, PA 19104, USA.

6. The Wistar Institute, Philadelphia, PA 19104, USA.

7. Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City 14080, Mexico.

8. Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.

9. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

10. Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

11. Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR 97239, USA.

12. Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Portland, OR 97239, USA.

13. Department of Medicine, University of California, San Francisco General Hospital, San Francisco, CA 94110, USA.

14. Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden.

Abstract

Elite control of HIV replication is linked to polyfunctional lymphoid CD8 + T cells that lack overt cytolytic activity and home to B cell follicles.

Funder

National Institutes of Health

Wellcome Trust

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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