Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Author:

Jaynes Jesse M.12ORCID,Sable Rushikesh3ORCID,Ronzetti Michael4ORCID,Bautista Wendy5ORCID,Knotts Zachary3ORCID,Abisoye-Ogunniyan Abisola26ORCID,Li Dandan3,Calvo Raul4,Dashnyam Myagmarjav4ORCID,Singh Anju4,Guerin Theresa5ORCID,White Jason2,Ravichandran Sarangan7ORCID,Kumar Parimal8ORCID,Talsania Keyur9,Chen Vicky9ORCID,Ghebremedhin Anghesom2,Karanam Balasubramanyam2ORCID,Bin Salam Ahmad2ORCID,Amin Ruksana2,Odzorig Taivan3ORCID,Aiken Taylor610ORCID,Nguyen Victoria3,Bian Yansong3,Zarif Jelani C.1112,de Groot Amber E.1314,Mehta Monika8,Fan Lixin15,Hu Xin4,Simeonov Anton4,Pate Nathan5ORCID,Abu-Asab Mones16ORCID,Ferrer Marc4,Southall Noel4ORCID,Ock Chan-Young17,Zhao Yongmei9ORCID,Lopez Henry18ORCID,Kozlov Serguei5ORCID,de Val Natalia1920ORCID,Yates Clayton C.2ORCID,Baljinnyam Bolormaa4ORCID,Marugan Juan4ORCID,Rudloff Udo3ORCID

Affiliation:

1. College of Agriculture, Environment and Nutrition Sciences, Integrative Biosciences Program, Tuskegee University, Tuskegee, AL 36088, USA.

2. Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.

3. Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

4. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.

5. Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.

6. Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

7. Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA.

8. Sequencing Facility and Single Cell Analysis Facility, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.

9. CCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.

10. Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.

11. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

12. Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

13. James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

14. Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.

15. Basic Science Program, Frederick National Laboratory for Cancer Research, SAXS Core Facility, Center for Cancer Research of the National Cancer Institute, Frederick, MD 21701, USA.

16. Section of Histopathology, National Eye Institute, Bethesda, MD 20892, USA.

17. Department of Hemato Oncology, Seoul National University Hospital, Seoul 03080, Korea.

18. MuriGenics Inc., Vallejo, CA 94592, USA.

19. Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA.

20. Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 21701, USA.

Abstract

Innate defense regulator RP-182 targets CD206 high M2-like macrophages in malignant and noncancerous diseases.

Funder

National Institutes of Health

U.S. Department of Defense

National Cancer Institute

National Center for Advancing Translational Sciences

National Institute on Minority Health and Health Disparities

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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