Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy-Reference-Cited by-同舟云学术

Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy

Published:2019-12-11 Issue:522 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Klufa Jörg¹^ORCID,Bauer Thomas¹^ORCID,Hanson Buck²^ORCID,Herbold Craig²^ORCID,Starkl Philipp³⁴^ORCID,Lichtenberger Beate¹^ORCID,Srutkova Dagmar⁵^ORCID,Schulz Daniel⁶^ORCID,Vujic Igor⁷⁸,Mohr Thomas¹^ORCID,Rappersberger Klemens⁷,Bodenmiller Bernd⁶,Kozakova Hana⁵^ORCID,Knapp Sylvia³⁴^ORCID,Loy Alexander²^ORCID,Sibilia Maria¹^ORCID

Affiliation:

1. Institute of Cancer Research, Department of Medicine I, Medical University of Vienna and Comprehensive Cancer Center, Vienna 1090, Austria.

2. Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Research Network Chemistry meets Microbiology, University of Vienna, Vienna 1090, Austria.

3. CeMM—Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna 1090, Austria.

4. Laboratory of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna 1090, Austria.

5. Laboratory of Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, v.v.i., Novy Hradek 549 22, Czech Republic.

6. Institute of Molecular Life Sciences, University of Zurich, Zurich 8057, Switzerland.

7. Department of Dermatology and Venereology, Medical Institution Rudolfstiftung, Vienna 1030, Austria.

8. Department of Dermatology, Medical University of Vienna, Vienna 1090, Austria.

Abstract

EGFR/ERK signaling in Lrig1 + stem cells secures barrier integrity during hair eruption to protect from invasion of commensal microbiota.

Funder

Swiss National Science Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference55 articles.

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