Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip-Reference-Cited by-同舟云学术

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

Published:2020-10-14 Issue:565 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yadid Moran¹²^ORCID,Lind Johan U.¹²³^ORCID,Ardoña Herdeline Ann M.¹^ORCID,Sheehy Sean P.¹²,Dickinson Lauren E.¹²^ORCID,Eweje Feyisayo¹²^ORCID,Bastings Maartje M.C.²⁴⁵⁶,Pope Benjamin¹²^ORCID,O’Connor Blakely B.¹^ORCID,Straubhaar Juerg R.⁷^ORCID,Budnik Bogdan⁷^ORCID,Kleber Andre G.⁸,Parker Kevin Kit¹²^ORCID

Affiliation:

1. Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

3. Department of Health Technology, Technical University of Denmark, Kgs. Lyngby 2800, Denmark.

4. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

5. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

6. Ecole Polytechnique Federale Lausanne (EPFL), School of Engineering, Institute of Materials, Programmable Biomaterials Laboratory, Station 12, 1015 Lausanne, Switzerland.

7. FAS Division of Science, Harvard University, Cambridge, MA 02138, USA.

8. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Endothelial extracellular vesicles containing cardioprotective proteins rescue engineered human cardiac tissue in an ischemia-reperfusion injury model.

Funder

National Institutes of Health

National Center for Advancing Translational Sciences of the National Institutes of Health

Harvard Materials Research Science and Engineering Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference87 articles.

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4. Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: Trials and tribulations;Hausenloy D. J.;Eur. Heart J.,2017

5. Cell Biology of Ischemia/Reperfusion Injury

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