Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

Author:

Yadid Moran12ORCID,Lind Johan U.123ORCID,Ardoña Herdeline Ann M.1ORCID,Sheehy Sean P.12,Dickinson Lauren E.12ORCID,Eweje Feyisayo12ORCID,Bastings Maartje M.C.2456,Pope Benjamin12ORCID,O’Connor Blakely B.1ORCID,Straubhaar Juerg R.7ORCID,Budnik Bogdan7ORCID,Kleber Andre G.8,Parker Kevin Kit12ORCID

Affiliation:

1. Disease Biophysics Group, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

3. Department of Health Technology, Technical University of Denmark, Kgs. Lyngby 2800, Denmark.

4. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

5. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

6. Ecole Polytechnique Federale Lausanne (EPFL), School of Engineering, Institute of Materials, Programmable Biomaterials Laboratory, Station 12, 1015 Lausanne, Switzerland.

7. FAS Division of Science, Harvard University, Cambridge, MA 02138, USA.

8. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Endothelial extracellular vesicles containing cardioprotective proteins rescue engineered human cardiac tissue in an ischemia-reperfusion injury model.

Funder

National Institutes of Health

National Center for Advancing Translational Sciences of the National Institutes of Health

Harvard Materials Research Science and Engineering Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference87 articles.

1. Heart disease and stroke statistics—2016 update: A report from the American Heart Association;Mozaffarian D.;Circulation,2016

2. Myocardial ischemia-reperfusion injury: a neglected therapeutic target

3. Myocardial Reperfusion Injury

4. Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: Trials and tribulations;Hausenloy D. J.;Eur. Heart J.,2017

5. Cell Biology of Ischemia/Reperfusion Injury

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