Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response-Reference-Cited by-同舟云学术

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response

Published:2019-10-30 Issue:516 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sharon David¹^ORCID,Cathelin Severine¹,Mirali Sara¹,Di Trani Justin M.²^ORCID,Yanofsky David J.²³^ORCID,Keon Kristine A.²³^ORCID,Rubinstein John L.²³^ORCID,Schimmer Aaron D.¹³,Ketela Troy¹,Chan Steven M.¹³^ORCID

Affiliation:

1. Princess Margaret Cancer Centre, Toronto, Ontario M5G 1L7, Canada.

2. Molecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

3. Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

Abstract

Tedizolid, an oxazolidinone-class antibiotic, overcomes resistance to venetoclax in AML.

Funder

Cancer Research Society

Leukemia and Lymphoma Society of Canada

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference73 articles.

1. An update of current treatments for adult acute myeloid leukemia

2. Age and acute myeloid leukemia

3. Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

4. Decoding and unlocking the BCL-2 dependency of cancer cells

5. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Cited by 140 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator;Cell Death & Disease;2024-08-27

2. Mitohormesis : la clé de voûte de la résistance thérapeutique des cellules cancéreuses;Comptes Rendus. Biologies;2024-08-22

3. Drug tolerant persister cell plasticity in cancer: a revolutionary strategy for more effective anticancer therapies;Signal Transduction and Targeted Therapy;2024-08-14

4. Mitochondrial bioenergetics as a cell fate rheostat for responsive to Bcl-2 drugs: New cues for cancer chemotherapy;Cancer Letters;2024-07

5. ONC212 enhances YM155 cytotoxicity by triggering SLC35F2 expression and NOXA-dependent MCL1 degradation in acute myeloid leukemia cells;Biochemical Pharmacology;2024-06