Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

Author:

Stokholm Jakob12ORCID,Thorsen Jonathan1ORCID,Blaser Martin J.34,Rasmussen Morten A.15ORCID,Hjelmsø Mathis1ORCID,Shah Shiraz1ORCID,Christensen Emil D.1ORCID,Chawes Bo L.1,Bønnelykke Klaus1,Brix Susanne6ORCID,Mortensen Martin S.7ORCID,Brejnrod Asker78ORCID,Vestergaard Gisle79ORCID,Trivedi Urvish7ORCID,Sørensen Søren J.7ORCID,Bisgaard Hans1ORCID

Affiliation:

1. COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, 2820 Copenhagen, Denmark.

2. Department of Pediatrics, Slagelse Hospital, 4200 Slagelse, Denmark.

3. Departments of Medicine and Microbiology and Human Microbiome Program, New York University Langone Medical Center, New York, NY 10016, USA.

4. Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USA.

5. Section of Chemometrics and Analytical Technologies, Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.

6. Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.

7. Section of Microbiology, Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.

8. San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, CA 92093, USA.

9. Section of Bioinformatics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.

Abstract

Cesarean section delivery is associated with gut microbiota differences and an increased risk of asthma by age six.

Funder

National Institutes of Health

Thrasher Research Fund

Lundbeckfonden

Novo Nordisk Fonden

Danish Council for Strategic Research

The Danish Ministry of Health

Danish Council for Independent Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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