The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

Author:

de Breij Anna1ORCID,Riool Martijn2ORCID,Cordfunke Robert A.3,Malanovic Nermina4,de Boer Leonie2ORCID,Koning Roman I.56ORCID,Ravensbergen Elisabeth1,Franken Marnix1,van der Heijde Tobias1,Boekema Bouke K.7ORCID,Kwakman Paulus H. S.2,Kamp Niels8,El Ghalbzouri Abdelouahab9,Lohner Karl4,Zaat Sebastian A. J.2ORCID,Drijfhout Jan W.3,Nibbering Peter H.1ORCID

Affiliation:

1. Department of Infectious Diseases, Leiden University Medical Center, 2300 RC Leiden, Netherlands.

2. Department of Medical Microbiology, Amsterdam Infection and Immunity Institute, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.

3. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, Netherlands.

4. Biophysics Division, Institute of Molecular Biosciences, University of Graz, Naturwissenschaftliche Fakultät (NAWI) Graz, BioTechMed, 8010 Graz, Austria.

5. Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, Netherlands.

6. Netherlands Center for Electron Nanoscopy, Institute of Biology Leiden, Leiden University, 2300 RA Leiden, Netherlands.

7. Association of Dutch Burn Centres, 1942 LT Beverwijk, Netherlands.

8. Animal Research Institute, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.

9. Department of Dermatology, Leiden University Medical Center, 2300 RC Leiden, Netherlands.

Abstract

Infections refractory to conventional antibiotics may be targeted by the antimicrobial peptide SAAP-148.

Funder

FP7-Health-2011

LSH-TKI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference68 articles.

1. K. Lohner E. Staudegger Are we on the threshold of the post-antibiotic era? in Development of Novel Antimicrobial Agents: Emerging Strategies K. Lohner Ed. (Horizin Scientific Press 2001).

2. J. O’Neill Tackling drug-resistant infections globally: Final report and recommendations (Review on Antimicrobial Resistance 2016); http://amr-review.org/sites/default/files/160525_Final%20paper_with%20cover.pdf.

3. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

4. The biofilm matrix

5. Biofilm-specific antibiotic tolerance and resistance

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