Epigenetic immune cell counting in human blood samples for immunodiagnostics

Author:

Baron Udo1ORCID,Werner Jeannette1ORCID,Schildknecht Konstantin1ORCID,Schulze Janika J.1ORCID,Mulu Andargaschew23,Liebert Uwe-Gerd2,Sack Ulrich4,Speckmann Carsten5,Gossen Manfred67ORCID,Wong Ronald J.8ORCID,Stevenson David K.8,Babel Nina9,Schürmann Dirk10,Baldinger Tina1,Bacchetta Rosa11,Grützkau Andreas12ORCID,Borte Stephan1314ORCID,Olek Sven1ORCID

Affiliation:

1. Ivana Türbachova Laboratory for Epigenetics, Epiontis GmbH, Precision for Medicine Group, 12489 Berlin, Germany.

2. Institute of Virology, Faculty of Medicine, University Leipzig, 04009 Leipzig, Germany.

3. Armauer Hansen Research Institute, 1005 Addis Ababa, Ethiopia.

4. Institute of Clinical Immunology, Faculty of Medicine, University Leipzig, 04009 Leipzig, Germany.

5. Center for Chronic Immunodeficiency and Department of Pediatric and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany.

6. Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, 14513 Teltow, Germany.

7. Berlin-Brandenburg Center for Regenerative Therapies, 13353 Berlin, Germany.

8. Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

9. Marienhospital Herne, Medizinische Klinik I, Universität Bochum, 44625 Herne, Germany.

10. Charité Universitätsmedizin Berlin, 13353 Berlin, Germany.

11. Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.

12. Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Immune Monitoring Core Facility, 10117 Berlin, Germany.

13. ImmunoDeficiencyCenter Leipzig, Municipal Hospital St. Georg Leipzig, 04129 Leipzig, Germany.

14. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge at Karolinska Institutet, 14186 Stockholm, Sweden.

Abstract

Epigenetic immune cell counting provides a potentially more robust platform to diagnose immune defects in adults and newborns.

Funder

Jeffrey Modell Foundation

German Federal Minitry of Education and Research

Federal Ministry for Economic Affairs

Stanford SPARK program

Federal Ministry for Research

Federal Ministry of Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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