Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Author:

Ishihara Jun12ORCID,Fukunaga Kazuto123ORCID,Ishihara Ako1ORCID,Larsson Hans M.2,Potin Lambert12ORCID,Hosseinchi Peyman1ORCID,Galliverti Gabriele2ORCID,Swartz Melody A.1245ORCID,Hubbell Jeffrey A.125ORCID

Affiliation:

1. Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.

2. Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

3. Department of Bioengineering, Tokyo Institute of Technology, 226-8501 Yokohama, Kanagawa, Japan.

4. Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

5. Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

Abstract

Matrix-binding peptide conjugation to immune checkpoint blockade antibodies enhances antitumor efficacy and reduces adverse events.

Funder

the European Research Commission grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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