Direct detection of early-stage cancers using circulating tumor DNA-Reference-Cited by-同舟云学术

Direct detection of early-stage cancers using circulating tumor DNA

Published:2017-08-16 Issue:403 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Phallen Jillian¹^ORCID,Sausen Mark²,Adleff Vilmos¹,Leal Alessandro¹^ORCID,Hruban Carolyn¹,White James¹,Anagnostou Valsamo¹^ORCID,Fiksel Jacob¹^ORCID,Cristiano Stephen¹^ORCID,Papp Eniko¹^ORCID,Speir Savannah¹^ORCID,Reinert Thomas³^ORCID,Orntoft Mai-Britt Worm³,Woodward Brian D.⁴^ORCID,Murphy Derek²^ORCID,Parpart-Li Sonya²,Riley David²,Nesselbush Monica²,Sengamalay Naomi²,Georgiadis Andrew²,Li Qing Kay¹,Madsen Mogens Rørbæk⁵,Mortensen Frank Viborg⁶,Huiskens Joost⁷⁸^ORCID,Punt Cornelis⁸^ORCID,van Grieken Nicole⁹^ORCID,Fijneman Remond¹⁰^ORCID,Meijer Gerrit¹⁰,Husain Hatim⁴,Scharpf Robert B.¹^ORCID,Diaz Luis A.¹^ORCID,Jones Siân²,Angiuoli Sam²^ORCID,Ørntoft Torben³^ORCID,Nielsen Hans Jørgen¹¹^ORCID,Andersen Claus Lindbjerg³^ORCID,Velculescu Victor E.¹^ORCID

Affiliation:

1. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2. Personal Genome Diagnostics, Baltimore, MD 21224, USA.

3. Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.

4. Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

5. Department of Surgery, Herning Regional Hospital, DK-7400 Herning, Denmark.

6. Department of Surgical Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark.

7. Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

8. Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

9. Department of Pathology, VU University Medical Center, Amsterdam 1081 HV, Netherlands.

10. Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands.

11. Department of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark.

Abstract

Noninvasive liquid biopsy analysis of circulating tumor DNA permits direct detection of early-stage cancers.

Funder

NIH Office of the Director

Commonwealth Foundation

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Stand Up To Cancer

Novo Nordisk

Danish Council for Independent Research

The Danish Council for Strategic Research

The Danish Cancer Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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