Direct detection of early-stage cancers using circulating tumor DNA

Author:

Phallen Jillian1ORCID,Sausen Mark2,Adleff Vilmos1,Leal Alessandro1ORCID,Hruban Carolyn1,White James1,Anagnostou Valsamo1ORCID,Fiksel Jacob1ORCID,Cristiano Stephen1ORCID,Papp Eniko1ORCID,Speir Savannah1ORCID,Reinert Thomas3ORCID,Orntoft Mai-Britt Worm3,Woodward Brian D.4ORCID,Murphy Derek2ORCID,Parpart-Li Sonya2,Riley David2,Nesselbush Monica2,Sengamalay Naomi2,Georgiadis Andrew2,Li Qing Kay1,Madsen Mogens Rørbæk5,Mortensen Frank Viborg6,Huiskens Joost78ORCID,Punt Cornelis8ORCID,van Grieken Nicole9ORCID,Fijneman Remond10ORCID,Meijer Gerrit10,Husain Hatim4,Scharpf Robert B.1ORCID,Diaz Luis A.1ORCID,Jones Siân2,Angiuoli Sam2ORCID,Ørntoft Torben3ORCID,Nielsen Hans Jørgen11ORCID,Andersen Claus Lindbjerg3ORCID,Velculescu Victor E.1ORCID

Affiliation:

1. The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2. Personal Genome Diagnostics, Baltimore, MD 21224, USA.

3. Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.

4. Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

5. Department of Surgery, Herning Regional Hospital, DK-7400 Herning, Denmark.

6. Department of Surgical Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark.

7. Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

8. Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

9. Department of Pathology, VU University Medical Center, Amsterdam 1081 HV, Netherlands.

10. Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands.

11. Department of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark.

Abstract

Noninvasive liquid biopsy analysis of circulating tumor DNA permits direct detection of early-stage cancers.

Funder

NIH Office of the Director

Commonwealth Foundation

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Stand Up To Cancer

Novo Nordisk

Danish Council for Independent Research

The Danish Council for Strategic Research

The Danish Cancer Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference39 articles.

1. Global cancer statistics, 2012

2. World Health Organization Guide to Cancer Early Diagnosis (World Health Organization 2017).

3. Prostate tissue and serum markers;Mazzucchelli R.;Adv. Clin. Path.,2000

4. CEA Serum Levels in Non-Neoplastic Disease

5. CA 19-9: handle with care

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