Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

Author:

Wolach Ofir123ORCID,Sellar Rob S.145ORCID,Martinod Kimberly6ORCID,Cherpokova Deya6,McConkey Marie1ORCID,Chappell Ryan J.1,Silver Alexander J.1ORCID,Adams Dylan1,Castellano Cecilia A.1,Schneider Rebekka K.17,Padera Robert F.8ORCID,DeAngelo Daniel J.9,Wadleigh Martha9,Steensma David P.9ORCID,Galinsky Ilene9ORCID,Stone Richard M.9,Genovese Giulio510ORCID,McCarroll Steven A.510,Iliadou Bozenna11,Hultman Christina11ORCID,Neuberg Donna9ORCID,Mullally Ann159,Wagner Denisa D.6ORCID,Ebert Benjamin L.159ORCID

Affiliation:

1. Division of Hematology, Brigham and Women’s Hospital, Boston, MA 02115, USA.

2. Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, Israel.

3. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 49100, Israel.

4. Department of Haematology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.

5. Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.

6. Program in Cellular and Molecular Medicine and Division of Hematology/Oncology, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

7. Department of Hematology, Cancer Institute, Erasmus Medical Center, Rotterdam 2040, Netherlands.

8. Department of Pathology, Brigham and Women’s Hospital, Boston Children’s Hospital, and Harvard Medical School, Boston, MA 02115, USA.

9. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

10. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

11. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE-171 76, Sweden.

Abstract

Thrombosis in myeloproliferative neoplasms is associated with increased NETosis that can be targeted with JAK inhibitors.

Funder

National Institutes of Health

Howard Hughes Medical Institute

Leukemia and Lymphoma Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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