Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia-Reference-Cited by-同舟云学术

Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia

Published:2017-10-18 Issue:412 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ng Alvin W. T.¹²³^ORCID,Poon Song Ling⁴^ORCID,Huang Mi Ni¹²,Lim Jing Quan⁴⁵^ORCID,Boot Arnoud¹²^ORCID,Yu Willie¹²^ORCID,Suzuki Yuka¹²^ORCID,Thangaraju Saranya⁴^ORCID,Ng Cedric C. Y.⁴^ORCID,Tan Patrick²⁶⁷⁸,Pang See-Tong⁹,Huang Hao-Yi¹⁰,Yu Ming-Chin¹¹^ORCID,Lee Po-Huang¹²,Hsieh Sen-Yung¹⁰^ORCID,Chang Alex Y.¹³^ORCID,Teh Bin T.²⁴⁷¹⁴^ORCID,Rozen Steven G.¹²³⁷^ORCID

Affiliation:

1. Centre for Computational Biology, Duke-NUS Medical School, Singapore 169857, Singapore.

2. Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore.

3. NUS Graduate School for Integrative Sciences and Engineering, Singapore 117456, Singapore.

4. Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Centre Singapore, Singapore 169610, Singapore.

5. Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore.

6. Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.

7. SingHealth/Duke-NUS Precision Medicine Institute, Singapore 169609, Singapore.

8. Genome Institute of Singapore, Singapore 138672, Singapore.

9. Division of Urooncology, Department of Urology, Chang Gung University and Memorial Hospital, Linkou, Taoyuan 33305, Taiwan.

10. Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan.

11. Department of General Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan.

12. Department of Surgery, National Taiwan University, Taipei 10051, Taiwan.

13. Johns Hopkins Singapore, Singapore 308433, Singapore.

14. Institute of Molecular and Cell Biology, Singapore 138673, Singapore.

Abstract

Mutational signatures reveal high burdens of aristolochic acid–related mutations in Asian liver cancers, with Taiwan most intensely affected.

Funder

National Medical Research Council

Ministry of Health -Singapore

Chang Gung Medical Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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