Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis-Reference-Cited by-同舟云学术

Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis

Published:2018-01-03 Issue:422 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Richards Duncan B.¹^ORCID,Cookson Louise M.¹,Barton Sharon V.¹,Liefaard Lia¹,Lane Thirusha²,Hutt David F.²,Ritter James M.³^ORCID,Fontana Marianna²,Moon James C.⁴^ORCID,Gillmore Julian D.²,Wechalekar Ashutosh²,Hawkins Philip N.²,Pepys Mark B.²⁵^ORCID

Affiliation:

1. GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, UK.

2. National Health Service National Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, University College London and Royal Free Hospital, London NW3 2PF, UK.

3. Quintiles Drug Research Unit, Guy’s Hospital, London SE1 1YR, UK.

4. University College London Institute of Cardiovascular Science and Barts Heart Centre, St Bartholomew’s Hospital, London EC1A 7BE, UK.

5. Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, University College London, London NW3 2PF, UK.

Abstract

Repeat cycles of miridesap, to deplete circulating serum amyloid P component (SAP), followed by the anti-SAP antibody, dezamizumab, cleared visceral amyloid deposits in patients with systemic amyloidosis.

Funder

GlaxoSmithKline

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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2. Antibodies to human serum amyloid P component eliminate visceral amyloid deposits;Bodin K.;Nature,2010

3. Therapeutic clearance of amyloid by antibodies to serum amyloid P component;Richards D. B.;N. Engl. J. Med.,2015

4. Amyloid P component. A critical review;Pepys M. B.;Amyloid,1997

5. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis;Pepys M. B.;Nature,2002

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