A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir

Author:

Tao Dingyin12ORCID,McGill Brent12ORCID,Hamerly Timothy123ORCID,Kobayashi Tamaki24,Khare Prachi3,Dziedzic Amanda1ORCID,Leski Tomasz5ORCID,Holtz Andrew6ORCID,Shull Bruce7,Jedlicka Anne E.1ORCID,Walzer Andrew7ORCID,Slowey Paul D.8ORCID,Slowey Christopher C.8,Nsango Sandrine E.910,Stenger David A.5,Chaponda Mike11ORCID,Mulenga Modest11,Jacobsen Kathryn H.12ORCID,Sullivan David J.1,Ryan Sadie J.13ORCID,Ansumana Rashid14,Moss William J.24,Morlais Isabelle9ORCID,Dinglasan Rhoel R.123ORCID

Affiliation:

1. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

2. Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.

3. Emerging Pathogens Institute and Department of Infectious Diseases & Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA.

4. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

5. United States Naval Research Laboratory (NRL), Center for Biomolecular Science and Engineering, Washington, DC 20375, USA.

6. College of Science, George Mason University, Fairfax, VA 22030, USA.

7. Thermo Fisher Scientific, Fremont, CA 94538, USA.

8. Oasis Diagnostics, Vancouver, WA 98686, USA.

9. Laboratoire de Recherche sur le Paludisme, Institut de Recherche pour le Développement–Organisation de Coordination et de Coopération pour la Lutte Contre les Grandes Endémies en Afrique Centrale (IRD-OCEAC), Yaoundé, Cameroon.

10. Faculty of Medicine and Pharmaceutical Sciences, University of Douala, PO Box 2701, Douala, Cameroon.

11. Tropical Disease Research Centre, Ndola, Zambia.

12. College of Health and Human Services, George Mason University, Fairfax, VA 22030, USA.

13. Emerging Pathogens Institute and Department of Geography, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL 32611, USA.

14. Mercy Hospital Research Laboratory, Kulanda Town, Bo, Sierra Leone.

Abstract

A noninvasive malaria rapid test assesses subclinical carriage of Plasmodium falciparum (human malaria) parasites at the point of need.

Funder

Defense Threat Reduction Agency

Bill & Melinda Gates Foundation

TEDCO Maryland Innovation Initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference44 articles.

1. World Health Organization World Malaria Report (World Health Organization 2017).

2. A novel Plasmodium falciparum sporozoite and liver stage antigen (SALSA) defines major B, T helper, and CTL epitopes;Bottius E.;J. Immunol.,1996

3. Working without a blindfold: the critical role of diagnostics in malaria control

4. The complexities of malaria disease manifestations with a focus on asymptomatic malaria

5. Asymptomatic malaria infections: detectability, transmissibility and public health relevance

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