PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL + human leukemia-Reference-Cited by-同舟云学术

PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL + human leukemia

Published:2018-02-07 Issue:427 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lai Damian¹²^ORCID,Chen Min¹^ORCID,Su Jiechuang¹³^ORCID,Liu Xiaohu¹²,Rothe Katharina¹³,Hu Kaiji¹,Forrest Donna L.²⁴,Eaves Connie J.¹²³^ORCID,Morin Gregg B.³⁵^ORCID,Jiang Xiaoyan¹²³^ORCID

Affiliation:

1. Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.

2. Department of Medicine, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.

3. Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.

4. Leukemia/Bone Marrow Transplant Program of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.

5. Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.

Abstract

PP2A inhibitors and BCR-ABL inhibitors synergize to kill drug-insensitive leukemia cells.

Funder

Canadian Institutes of Health Research

Canadian Cancer Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference67 articles.

1. Five-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid Leukemia

2. Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor

3. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

4. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl

5. Patients with chronic myeloid leukemia who maintain a complete molecular response after stopping imatinib treatment have evidence of persistent leukemia by DNA PCR

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