Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins-Reference-Cited by-同舟云学术

Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins

Published:2017-09-06 Issue:406 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Xu Yongmei¹^ORCID,Chandarajoti Kasemsiri²³^ORCID,Zhang Xing⁴,Pagadala Vijayakanth¹^ORCID,Dou Wenfang¹,Hoppensteadt Debra Moorman⁵^ORCID,Sparkenbaugh Erica M.²^ORCID,Cooley Brian⁶^ORCID,Daily Sharon⁷^ORCID,Key Nigel S.²,Severynse-Stevens Diana⁷^ORCID,Fareed Jawed⁵,Linhardt Robert J.⁴^ORCID,Pawlinski Rafal²^ORCID,Liu Jian¹^ORCID

Affiliation:

1. Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

2. Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

3. Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.

4. Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

5. Department of Pathology, Loyola University Medical Center, Maywood, IL 60660, USA.

6. Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

7. Center for Global Health, RTI International, Research Triangle Park, NC 27709, USA.

Abstract

A synthetic homogeneous low–molecular weight heparin provides a safe and effective therapeutic alternative.

Funder

National Institutes of Health

Eshelman Innovation Institute

North Carolina Translational & Clinical Sciences Institute

Glycan Therapeutics

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference57 articles.

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5. Reducing the hospital burden of heparin-induced thrombocytopenia: impact of an avoid-heparin program

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