T cell–induced CSF1 promotes melanoma resistance to PD1 blockade-Reference-Cited by-同舟云学术

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Published:2018-04-11 Issue:436 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Neubert Natalie J.¹^ORCID,Schmittnaegel Martina²^ORCID,Bordry Natacha¹^ORCID,Nassiri Sina²,Wald Noémie¹,Martignier Christophe¹^ORCID,Tillé Laure¹^ORCID,Homicsko Krisztian¹²,Damsky William³^ORCID,Maby-El Hajjami Hélène¹^ORCID,Klaman Irina⁴,Danenberg Esther⁵,Ioannidou Kalliopi¹^ORCID,Kandalaft Lana⁵^ORCID,Coukos George¹⁵^ORCID,Hoves Sabine⁴^ORCID,Ries Carola H.⁴^ORCID,Fuertes Marraco Silvia A.¹,Foukas Periklis G.⁵,De Palma Michele²^ORCID,Speiser Daniel E.¹^ORCID

Affiliation:

1. Ludwig Cancer Research Center and Department of Oncology, University of Lausanne (UNIL), CH-1066 Epalinges, Switzerland.

2. Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

3. Departments of Dermatology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.

4. Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Nonnenwald 2, D-82377 Penzberg, Germany.

5. Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital (CHUV), CH-1005 Lausanne, Switzerland.

Abstract

T cells promote immunosuppression in melanoma through CSF1 induction and macrophage recruitment.

Funder

Cancer Research Institute

Swiss National Science Foundation

Fondation Leenaards

Emma Muschamp Foundation

Swiss Cancer Research

Swiss TransMed