TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence-Reference-Cited by-同舟云学术

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Published:2018-08-15 Issue:454 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bird Thomas G.¹²³^ORCID,Müller Miryam¹^ORCID,Boulter Luke²⁴^ORCID,Vincent David F.¹^ORCID,Ridgway Rachel A.¹,Lopez-Guadamillas Elena⁵,Lu Wei-Yu²^ORCID,Jamieson Thomas¹^ORCID,Govaere Olivier⁶^ORCID,Campbell Andrew D.¹,Ferreira-Gonzalez Sofía²^ORCID,Cole Alicia M.¹,Hay Trevor⁷^ORCID,Simpson Kenneth J.²,Clark William¹,Hedley Ann¹^ORCID,Clarke Mairi⁸^ORCID,Gentaz Pauline¹^ORCID,Nixon Colin¹^ORCID,Bryce Steven¹^ORCID,Kiourtis Christos¹⁹^ORCID,Sprangers Joep¹,Nibbs Robert J. B.⁸^ORCID,Van Rooijen Nico¹⁰^ORCID,Bartholin Laurent¹¹^ORCID,McGreal Steven R.¹²^ORCID,Apte Udayan¹²,Barry Simon T.¹³,Iredale John P.³¹⁴,Clarke Alan R.⁷,Serrano Manuel⁵¹⁵^ORCID,Roskams Tania A.⁶^ORCID,Sansom Owen J.¹⁹^ORCID,Forbes Stuart J.²³^ORCID

Affiliation:

1. Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.

2. Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.

3. MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh EH164TJ, UK.

4. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh EH4 2XU, UK.

5. Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.

6. Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven, B-3000 Leuven, Belgium.

7. School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

8. Institute for Infection Immunity and Inflammation, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.

9. Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

10. Vrije Universiteit Medical Center, Department of Molecular Cell Biology, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands.

11. Centre de Recherche en Cancérologie de Lyon, UMR INSERM 1052, CNRS 5286, Lyon I University UMR S 1052, 69373 Lyon Cedex 08, France.

12. Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

13. Oncology, IMED Biotech Unit, AstraZeneca, Cambridge CB2 0AA, UK.

14. University of Bristol, Senate House, Tyndall Avenue, Bristol BS8 1TH, UK.

15. Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, and Catalan Institution for Research and Advanced Studies, Barcelona, Spain.

Abstract

Inhibiting acute injury–induced senescence mediated by TGFβ signaling in regenerative epithelium improves liver regeneration.

Funder

National Institutes of Health

Wellcome Trust

Medical Research Council

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference61 articles.