The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy

Author:

Krall Jordan A.1ORCID,Reinhardt Ferenc1,Mercury Oblaise A.1ORCID,Pattabiraman Diwakar R.1,Brooks Mary W.1,Dougan Michael12,Lambert Arthur W.1ORCID,Bierie Brian1,Ploegh Hidde L.13ORCID,Dougan Stephanie K.14,Weinberg Robert A.135ORCID

Affiliation:

1. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

2. Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.

3. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

4. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

5. Ludwig Center for Molecular Oncology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

Abstract

Anti-inflammatories prevent surgery-induced outgrowth of distant tumors in mouse models and may reduce early metastatic relapse in patients.

Funder

Breast Cancer Research Foundation

Samuel Waxman Cancer Research Foundation

Advanced Medical Research Foundation

Charles A. King Trust

Hope Funds for Cancer Research

Transcend Program

Ludwig Center for Molecular Oncology at MIT

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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