Malaria in pregnancy alters l -arginine bioavailability and placental vascular development-Reference-Cited by-同舟云学术

Malaria in pregnancy alters l -arginine bioavailability and placental vascular development

Published:2018-03-07 Issue:431 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

McDonald Chloe R.¹²^ORCID,Cahill Lindsay S.³⁴,Gamble Joel L.²^ORCID,Elphinstone Robyn²,Gazdzinski Lisa M.³⁴^ORCID,Zhong Kathleen J. Y.²,Philson Adrienne C.⁵,Madanitsa Mwayiwawo⁶^ORCID,Kalilani-Phiri Linda⁶,Mwapasa Victor⁶,ter Kuile Feiko O.⁷^ORCID,Sled John G.³⁴^ORCID,Conroy Andrea L.²⁸^ORCID,Kain Kevin C.¹²⁸^ORCID

Affiliation:

1. Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

2. Sandra A. Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

3. Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario M5T 3HT, Canada.

4. Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

5. Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02138, USA.

6. College of Medicine, University of Malawi, P.O. Box 280, Blantyre, Malawi.

7. Liverpool School of Tropical Medicine, Liverpool L35QA, UK.

8. Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario M5G 2C4, Canada.

Abstract

Malaria in pregnancy alters l -arginine biosynthesis in Malawian women, and l -arginine supplementation improves placental vasculature and birth outcomes in a preclinical model.

Funder

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference69 articles.

1. Quantifying the Number of Pregnancies at Risk of Malaria in 2007: A Demographic Study

2. World Health Organization (WHO) “World malaria report 2017” WHO. (2017)

3. S. J. Rogerson, M. Desai, A. Major, E. Sicuri, S. M. Taylor, A. M. van Eijk, Burden, pathology, and costs of malaria in pregnancy: New developments for an old problem. Lancet Infect. Dis., S1473-3099(18)30066-5 (2018).

4. Epidemiology and burden of malaria in pregnancy

5. The Sick Placenta—The Role of Malaria

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