The gut microbiota influences skeletal muscle mass and function in mice

Author:

Lahiri Shawon12ORCID,Kim Hyejin3ORCID,Garcia-Perez Isabel4ORCID,Reza Musarrat Maisha15ORCID,Martin Katherine A.3ORCID,Kundu Parag36ORCID,Cox Laura M.7ORCID,Selkrig Joel3ORCID,Posma Joram M.4ORCID,Zhang Hongbo8ORCID,Padmanabhan Parasuraman3ORCID,Moret Catherine2ORCID,Gulyás Balázs910ORCID,Blaser Martin J.1112,Auwerx Johan8ORCID,Holmes Elaine4ORCID,Nicholson Jeremy13,Wahli Walter2314,Pettersson Sven136ORCID

Affiliation:

1. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

2. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

3. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

4. Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW72AZ, UK.

5. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

6. Singapore Center for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.

7. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

8. Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

9. Department of Neuroscience and Mental Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

10. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

11. Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

12. Medical Service, VA New York Harbor Healthcare System, New York, NY 10010, USA.

13. Australian National Phenome Center, Murdoch University, WA 6150, Australia.

14. INRA ToxAlim Integrative Toxicology and Metabolism UMR1331, Chemin de Tournefeuille, Toulouse Cedex, France.

Abstract

Transplanting the gut microbiota of pathogen-free mice into germ-free mice improves skeletal muscle mass and strength.

Funder

Medical Research Council

Swiss National Science Foundation

Vetenskapsrådet

European Society for Clinical Nutrition and Metabolism

NIHR

TORNADO

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference47 articles.

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