Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain

Author:

Niño Diego F.12ORCID,Zhou Qinjie12ORCID,Yamaguchi Yukihiro12,Martin Laura Y.12,Wang Sanxia12,Fulton William B.12ORCID,Jia Hongpeng12ORCID,Lu Peng12,Prindle Thomas12,Zhang Fan3ORCID,Crawford Joshua4,Hou Zhipeng5ORCID,Mori Susumu5,Chen Liam L.6,Guajardo Andrew6,Fatemi Ali7,Pletnikov Mikhail48ORCID,Kannan Rangaramanujam M.9ORCID,Kannan Sujatha10,Sodhi Chhinder P.12,Hackam David J.12ORCID

Affiliation:

1. Division of General Pediatric Surgery, Johns Hopkins University and Bloomberg Children’s Center, Johns Hopkins Hospital, Baltimore, MD 21287, USA.

2. Division of General Pediatric Surgery, Johns Hopkins University and Johns Hopkins Children’s Center, Johns Hopkins Hospital, Baltimore, MD 21287, USA.

3. Program of Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

4. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

5. Department of Biomedical Engineering and The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

6. Division of Neuropathology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

7. Departments of Neurology and Pediatrics, Kennedy Krieger Institute and Johns Hopkins University School of Medicine, MD 21205, USA.

8. Department of Molecular and Comparative Pathobiology and Solomon H. Snyder Department of Neuroscience, Johns Hopkins University and Johns Hopkins Children’s Center, Johns Hopkins Hospital, Baltimore, MD 21205, USA.

9. Center for Nanomedicine, Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

10. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Necrotizing enterocolitis–induced brain injury in mice can be prevented with an oral nanotherapeutic that targets microglia.

Funder

National Institutes of Health

National Institute of Neurological Disorders and Stroke

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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