Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity-Reference-Cited by-同舟云学术

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity

Published:2019-02-06 Issue:478 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Saleme Bruno¹²^ORCID,Gurtu Vikram¹²,Zhang Yongneng¹²^ORCID,Kinnaird Adam¹³,Boukouris Aristeidis E.¹²^ORCID,Gopal Keshav²⁴,Ussher John R.²⁴,Sutendra Gopinath¹²⁵^ORCID

Affiliation:

1. Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.

2. Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.

3. Department of Surgery, University of Alberta, Edmonton, Alberta T6G 1Z1, Canada.

4. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2H1, Canada.

5. Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, Alberta T6G 2J7, Canada.

Abstract

The redox status of tetrameric PKM2 defines its differential regulation of p53 activity and apoptosis.

Funder

Heart and Stroke Foundation of Canada

Canadian Institutes of Health Research

Alberta Innovates - Health Solutions

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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