Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models-Reference-Cited by-同舟云学术

Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

Published:2019-02-13 Issue:479 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Papa Anne-Laure¹²^ORCID,Jiang Amanda³^ORCID,Korin Netanel¹^ORCID,Chen Michelle B.⁴,Langan Erin T.⁵^ORCID,Waterhouse Anna¹^ORCID,Nash Emma¹^ORCID,Caroff Jildaz⁵^ORCID,Graveline Amanda¹^ORCID,Vernet Andyna¹,Mammoto Akiko³,Mammoto Tadanori³,Jain Abhishek¹^ORCID,Kamm Roger D.⁴⁶^ORCID,Gounis Matthew J.⁵^ORCID,Ingber Donald E.¹³⁷^ORCID

Affiliation:

1. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

2. Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.

3. Vascular Biology Program and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. New England Center for Stroke Research, Department of Radiology, University of Massachusetts, Worcester, MA 01655, USA.

6. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7. Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA.

Abstract

Human platelet decoys prevented thrombosis in rabbits and inhibited cancer cell aggregation and extravasation in vitro and in a mouse model.

Funder

National Institutes of Health

U.S. Department of Defense

Wyss Institute at Harvard University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference36 articles.

1. Mechanisms of Hemostasis and Thrombosis

2. Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

3. Beyond Thrombosis

4. Anti-platelet agents augment cisplatin nanoparticle cytotoxicity by enhancing tumor vasculature permeability and drug delivery

5. Paraneoplastic Thrombocytosis in Ovarian Cancer

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