HBEGF + macrophages in rheumatoid arthritis induce fibroblast invasiveness

Author:

Kuo David12ORCID,Ding Jennifer3ORCID,Cohn Ian S.3,Zhang Fan4567ORCID,Wei Kevin8ORCID,Rao Deepak A.8ORCID,Rozo Cristina3,Sokhi Upneet K.3ORCID,Shanaj Sara3ORCID,Oliver David J.3,Echeverria Adriana P.3ORCID,DiCarlo Edward F.9,Brenner Michael B.8ORCID,Bykerk Vivian P.310ORCID,Goodman Susan M.310ORCID,Raychaudhuri Soumya45611ORCID,Rätsch Gunnar212ORCID,Ivashkiv Lionel B.31013ORCID,Donlin Laura T.310ORCID

Affiliation:

1. Graduate Program in Physiology, Biophysics and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

2. Computational Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.

3. Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA.

4. Center for Data Sciences, Brigham and Women's Hospital, Boston, MA 02115, USA.

5. Division of Rheumatology and Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

6. Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.

7. Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

8. Division of Rheumatology, Immunology, Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

9. Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA.

10. Weill Cornell Medical College, New York, NY 10021, USA.

11. Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester, UK.

12. Department of Computer Science, Universitätstrasse 6, ETH Zürich, 8092 Zürich, Switzerland

13. Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.

Abstract

Macrophages promote fibroblast invasiveness and demonstrate variable response to anti-inflammatory medications in patients with rheumatoid arthritis.

Funder

National Institutes of Health

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Memorial Sloan-Kettering Cancer Center

Eidgenössische Technische Hochschule Zürich

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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