Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Author:

Watt Matthew J.12ORCID,Clark Ashlee K.34,Selth Luke A.5ORCID,Haynes Vanessa R.12,Lister Natalie34,Rebello Richard346ORCID,Porter Laura H.34ORCID,Niranjan Birunthi34,Whitby Sarah T.23ORCID,Lo Jennifer2,Huang Cheng7ORCID,Schittenhelm Ralf B.7ORCID,Anderson Kimberley E.8,Furic Luc34910ORCID,Wijayaratne Poornima R.2ORCID,Matzaris Maria2,Montgomery Magdalene K.12,Papargiris Melissa34,Norden Sam11,Febbraio Maria12,Risbridger Gail P.34910ORCID,Frydenberg Mark13ORCID,Nomura Daniel K.8,Taylor Renea A.349ORCID

Affiliation:

1. Department of Physiology, University of Melbourne, Melbourne, VIC 3010, Australia.

2. Monash Biomedicine Discovery Institute, Metabolic Disease and Obesity, Department of Physiology, Monash University, Clayton, VIC 3800, Australia.

3. Monash Partners Comprehensive Cancer Consortium, Monash Biomedicine Discovery Institute Cancer Program, Prostate Cancer Research Group, Department of Physiology, Monash University, Clayton, VIC 3800, Australia.

4. Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia.

5. Dame Roma Mitchell Cancer Research Laboratories and Freemasons Foundation Centre for Men’s Health, Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.

6. Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4GJ, UK.

7. Monash Biomedical Proteomics Facility and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.

8. Departments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology, University of California, Berkley, Berkeley, CA, USA.

9. Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.

10. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia.

11. TissuPath, Mount Waverley, VIC 3149, Australia.

12. Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2R7, Canada.

13. Department of Surgery, Faculty of Medicine, Monash University, Clayton, VIC 3800, Australia.

Abstract

Prostate cancer depends on fatty acid uptake and remodeling of the prostate lipidome, and blocking fatty acid uptake impairs prostate tumorigenesis.

Funder

Victorian Cancer Agency

Diabetes Australia Research Trust

National Health and Medical Research Council

Prostate Cancer Foundation of Australia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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