Preclinical development of an oral anti- Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis-Reference-Cited by-同舟云学术

Preclinical development of an oral anti- Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

Published:2019-03-13 Issue:483 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Taylor Mark J.¹^ORCID,von Geldern Thomas W.²³^ORCID,Ford Louise¹^ORCID,Hübner Marc P.⁴^ORCID,Marsh Kennan²^ORCID,Johnston Kelly L.¹^ORCID,Sjoberg Hanna T.¹^ORCID,Specht Sabine⁴,Pionnier Nicolas¹^ORCID,Tyrer Hayley E.¹^ORCID,Clare Rachel H.¹^ORCID,Cook Darren A. N.¹,Murphy Emma¹^ORCID,Steven Andrew¹,Archer John¹,Bloemker Dominique⁴^ORCID,Lenz Franziska⁴^ORCID,Koschel Marianne⁴^ORCID,Ehrens Alexandra⁴^ORCID,Metuge Haelly M.⁵⁶^ORCID,Chunda Valerinne C.⁵⁶^ORCID,Ndongmo Chounna Patrick W.⁵⁶^ORCID,Njouendou Abdel J.⁵⁶^ORCID,Fombad Fanny F.⁵⁶^ORCID,Carr Robert²^ORCID,Morton Howard E.²^ORCID,Aljayyoussi Ghaith¹^ORCID,Hoerauf Achim⁴^ORCID,Wanji Samuel⁵⁶,Kempf Dale J.²^ORCID,Turner Joseph D.¹^ORCID,Ward Stephen A.¹^ORCID

Affiliation:

1. Centre for Drugs and Diagnostics, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

2. Global Pharmaceutical Research and Development, AbbVie, North Chicago, IL, USA.

3. Franciscan Institute for World Health, Franciscan University, Steubenville, OH, USA.

4. Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

5. Research Foundation for Tropical Diseases and the Environment, Buea, Cameroon.

6. Department of Microbiology and Parasitology, University of Buea, Buea, Cameroon.

Abstract

An oral macrolide drug targeting the bacterial endosymbiont, Wolbachia , shows efficacy against filarial nematodes in preclinical animal models.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference31 articles.

1. Neglected tropical diseases in Africa: a new paradigm

2. Multidimensional complexities of filariasis control in an era of large-scale mass drug administration programmes: a can of worms

3. Lymphatic filariasis and onchocerciasis

4. Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis

5. The Wolbachia endosymbiont as an anti-filarial nematode target

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