Activin type II receptor signaling in cardiac aging and heart failure

Author:

Roh Jason D.1ORCID,Hobson Ryan1ORCID,Chaudhari Vinita1ORCID,Quintero Pablo2,Yeri Ashish1,Benson Mark2ORCID,Xiao Chunyang1,Zlotoff Daniel1ORCID,Bezzerides Vassilios3,Houstis Nicholas1,Platt Colin1,Damilano Federico1,Lindman Brian R.4,Elmariah Sammy1ORCID,Biersmith Michael5,Lee Se-Jin67ORCID,Seidman Christine E.8910ORCID,Seidman Jonathan G.8ORCID,Gerszten Robert E.2,Lach-Trifilieff Estelle11,Glass David J.12ORCID,Rosenzweig Anthony1ORCID

Affiliation:

1. Corrigan Minehan Heart Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

2. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37203, USA.

5. Division of Cardiovascular Medicine, Wexner Medical Center, Ohio State University, Columbus, OH 43210, USA.

6. The Jackson Laboratory, Farmington, CT 06032, USA.

7. Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT 06032, USA.

8. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

9. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

10. Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA 02114, USA.

11. Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland.

12. Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

Abstract

Activin type II receptor signaling regulates cardiac function in aging and heart failure by modulating proteasome-dependent SERCA2a degradation.

Funder

National Institutes of Health

National Institute on Aging

National Heart, Lung, and Blood Institute

American Heart Association

Frederick and Ines Yeatts Fund for Innovative Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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