A direct-acting antiviral drug abrogates viremia in Zika virus–infected rhesus macaques-Reference-Cited by-同舟云学术

A direct-acting antiviral drug abrogates viremia in Zika virus–infected rhesus macaques

Published:2020-06-10 Issue:547 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lim So-Yon¹^ORCID,Osuna Christa E.¹^ORCID,Best Katharine²³,Taylor Ray⁴^ORCID,Chen Elsa¹^ORCID,Yoon Gyeol¹,Kublin Jessica L.¹,Schalk Dane⁵^ORCID,Schultz-Darken Nancy⁵^ORCID,Capuano Saverio⁵,Safronetz David⁶,Luo Ma⁶,MacLennan Steve⁴^ORCID,Mathis Amanda⁴,Babu Yarlagadda S.⁴^ORCID,Sheridan William P.⁴^ORCID,Perelson Alan S.³^ORCID,Whitney James B.¹⁷^ORCID

Affiliation:

1. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

2. Merck Science Center, Cambridge, MA 02141, USA.

3. Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

4. BioCryst Pharmaceuticals, Birmingham, AL 35244, USA.

5. Wisconsin National Primate Research Center, Madison, WI 53715, USA.

6. National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, R3E 3R2 Manitoba, Canada.

7. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

Abstract

Galidesivir, a broad-spectrum direct-acting adenosine analog antiviral drug, abrogates viremia in rhesus macaques infected with Zika virus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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