GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells-Reference-Cited by-同舟云学术

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells

Published:2019-03-27 Issue:485 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Smith Eric L.¹²^ORCID,Harrington Kim³,Staehr Mette¹^ORCID,Masakayan Reed¹^ORCID,Jones Jon³^ORCID,Long Thomas J.³,Ng Khong Y.⁴^ORCID,Ghoddusi Majid³^ORCID,Purdon Terence J.¹,Wang Xiuyan⁵,Do Trevor³,Pham Minh Thu³,Brown Jessica M.³^ORCID,De Larrea Carlos Fernandez¹⁶,Olson Eric³,Peguero Elizabeth⁴^ORCID,Wang Pei⁷,Liu Hong⁷,Xu Yiyang⁷,Garrett-Thomson Sarah C.⁸^ORCID,Almo Steven C.⁸,Wendel Hans-Guido⁴^ORCID,Riviere Isabelle⁵,Liu Cheng⁷,Sather Blythe³^ORCID,Brentjens Renier J.¹⁹^ORCID

Affiliation:

1. Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Juno Therapeutics, A Celgene Company, Seattle, WA 98109, USA.

4. Sloan Kettering Institute, New York, NY 10065, USA.

5. Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Amyloidosis and Myeloma Unit, Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, 08036 Barcelona, Spain.

7. Eureka Therapeutics, Emeryville, CA 94608, USA.

8. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

9. Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Abstract

GPRC5D is an attractive target for immunotherapy of myeloma, and optimized GPRC5D-targeted CAR T cells eradicate myeloma xenografts.

Funder

National Institutes of Health

National Cancer Institute

Multiple Myeloma Research Foundation

American Society of Hematology

Leukemia and Lymphoma Society

Publisher