PET ligands [ 18 F]LSN3316612 and [ 11 C]LSN3316612 quantify O -linked-β- N -acetyl-glucosamine hydrolase in the brain-Reference-Cited by-同舟云学术

PET ligands [ 18 F]LSN3316612 and [ 11 C]LSN3316612 quantify O -linked-β- N -acetyl-glucosamine hydrolase in the brain

Published:2020-05-13 Issue:543 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lu Shuiyu¹^ORCID,Haskali Mohammad B.¹^ORCID,Ruley Kevin M.²,Dreyfus Nicolas J.-F.³,DuBois Susan L.²,Paul Soumen¹,Liow Jeih-San¹,Morse Cheryl L.¹,Kowalski Aneta¹,Gladding Robert L.¹,Gilmore Jeremy³^ORCID,Mogg Adrian J.³^ORCID,Morin S. Michelle²,Lindsay-Scott Peter J.³,Ruble J. Craig²^ORCID,Kant Nancy A.²,Shcherbinin Sergey²,Barth Vanessa N.²,Johnson Michael P.²^ORCID,Cuadrado Maria⁴,Jambrina Enrique⁴,Mannes Andrew J.⁵^ORCID,Nuthall Hugh N.³,Zoghbi Sami S.¹,Jesudason Cynthia D.²,Innis Robert B.¹,Pike Victor W.¹^ORCID

Affiliation:

1. Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346, 10 Center Drive, Bethesda, MD 20892-1003, USA.

2. Eli Lilly and Co, Indianapolis, IN 46285, USA.

3. Eli Lilly and Co, Windlesham GU20 6PH, UK.

4. Lilly, S. A. Avenida de la Industria 30, 28108 Alcobendas, Madrid, Spain.

5. Department of Perioperative Medicine, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1510, USA.

Abstract

Two radioligands, [ 18 F]LSN3316612 and [ 11 C]LSN3316612, image and quantify brain O -linked-β- N -acetyl-glucosamine hydrolase in vivo.

Funder

National Institute of Mental Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

1. Tau: From research to clinical development

2. Tau and tauopathies

3. Roles of tau protein in health and disease

4. O-GlcNAc cycling: Implications for neurodegenerative disorders

5. A little sugar goes a long way: The cell biology of O-GlcNAc

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