Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies-Reference-Cited by-同舟云学术

Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies

Published:2019-07-03 Issue:499 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Panni Roheena Z.¹,Herndon John M.²^ORCID,Zuo Chong²,Hegde Samarth²^ORCID,Hogg Graham D.²,Knolhoff Brett L.²,Breden Marcus A.²,Li Xiaobo³,Krisnawan Varintra E.²^ORCID,Khan Samia Q.³,Schwarz Julie K.⁴⁵,Rogers Buck E.⁴⁵^ORCID,Fields Ryan C.¹⁴^ORCID,Hawkins William G.¹⁴^ORCID,Gupta Vineet³^ORCID,DeNardo David G.²⁴⁶^ORCID

Affiliation:

1. Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

4. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.

6. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Agonism of CD11b overcomes myeloid cell–induced immunosuppression to render pancreatic cancer models responsive to checkpoint immunotherapy.

Funder

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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