Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis-Reference-Cited by-同舟云学术

Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

Published:2019-02-06 Issue:478 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rosen Dorian A.¹²^ORCID,Seki Scott M.¹,Fernández-Castañeda Anthony¹^ORCID,Beiter Rebecca M.¹^ORCID,Eccles Jacob D.³^ORCID,Woodfolk Judith A.³,Gaultier Alban¹^ORCID

Affiliation:

1. Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

2. Graduate Program in Pharmacological Sciences, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

3. Division of Asthma, Allergy and Immunology, Department of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

Abstract

Sigma-1 receptor is a critical inhibitor of endoplasmic reticulum–driven inflammation and a potential therapeutic target in septic shock.

Funder

National Institute of General Medical Sciences

National Institute of Neurological Disorders and Stroke

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference49 articles.

1. RETRACTED: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling

2. Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

3. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

4. ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

5. Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

Cited by 229 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Assessing the effect of selective serotonin reuptake inhibitors in the prevention of post-acute sequelae of COVID-19;Computational and Structural Biotechnology Journal;2024-12

2. The immunomodulatory effects of classical psychedelics: A systematic review of preclinical studies;Progress in Neuro-Psychopharmacology and Biological Psychiatry;2024-09

3. Negative Prognostic Associations of Selective Serotonin Reuptake Inhibitors Use in Hospitalized COVID-19 Patients and Potential Contribution of Cardiovascular Comorbidities;Pharmacology;2024-07-31

4. A systematic review and meta-analysis, investigating dose and time of fluvoxamine treatment efficacy for COVID-19 clinical deterioration, death, and Long-COVID complications;Scientific Reports;2024-06-12

5. Fluvoxamine and long COVID: Post‐acute recovery;Reviews in Medical Virology;2024-06-02