Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

Author:

Sharma Geetanjali1ORCID,Hu Chelin2ORCID,Staquicini Daniela I.34,Brigman Jonathan L.5,Liu Meilian67ORCID,Mauvais-Jarvis Franck89,Pasqualini Renata34,Arap Wadih410,Arterburn Jeffrey B.11ORCID,Hathaway Helen J.212ORCID,Prossnitz Eric R.1712ORCID

Affiliation:

1. Division of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.

2. Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.

3. Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

4. Rutgers Cancer Institute of New Jersey, Newark, NJ 07103, USA.

5. Department of Neurosciences, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.

6. Department of Biochemistry and Molecular Biology, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.

7. Center of Biomedical Research Excellence in Autophagy, Inflammation and Metabolism, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.

8. Diabetes Discovery and Sex-Based Medicine Laboratory, Section of Endocrinology and Metabolism, Department of Medicine, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA.

9. Section of Endocrinology, Southeast Louisiana Veterans Administration Health Care System, New Orleans, LA 70112, USA.

10. Division of Hematology/Oncology, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

11. Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM, 88003, USA.

12. University of New Mexico Comprehensive Cancer Center, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.

Abstract

Targeting the G protein–coupled estrogen receptor GPER with a selective agonist ameliorates obesity and diabetes in mice.

Funder

National Cancer Institute

U.S. Department of Veterans Affairs

Gillson Longenbaugh Foundation

NIDDK

Dialysis Clinic, Inc

Gillson-Longenbaugh Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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