GDNF rescues the fate of neural progenitor grafts by attenuating Notch signals in the injured spinal cord in rodents

Author:

Khazaei Mohamad1ORCID,Ahuja Christopher S.12ORCID,Nakashima Hiroaki1,Nagoshi Narihito1,Li Lijun1ORCID,Wang Jian1ORCID,Chio Jonathon12,Badner Anna12ORCID,Seligman David1ORCID,Ichise Ayaka3,Shibata Shinsuke3ORCID,Fehlings Michael G.1245ORCID

Affiliation:

1. Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON M5T 0S8, Canada.

2. Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.

3. Electron Microscope Laboratory, Keio University School of Medicine, Tokyo 160-8582, Japan.

4. Department of Surgery, University of Toronto, Toronto, ON M5T 1P5, Canada.

5. Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.

Abstract

Glial-derived neurotrophic factor expression by grafted human neural progenitor cells enhances functional recovery after spinal cord injury.

Funder

Wings for Life

Canadian Institutes of Health Research

Krembil Foundation

Ontario Institute of Regenerative Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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