Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice

Author:

Kundu Parag123ORCID,Lee Hae Ung1,Garcia-Perez Isabel4ORCID,Tay Emmy Xue Yun5ORCID,Kim Hyejin1ORCID,Faylon Llanto Elma2ORCID,Martin Katherine A.1ORCID,Purbojati Rikky2ORCID,Drautz-Moses Daniela I.2,Ghosh Sujoy678ORCID,Nicholson Jeremy K.9,Schuster Stephan2ORCID,Holmes Elaine410ORCID,Pettersson Sven1211ORCID

Affiliation:

1. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.

2. Singapore Centre for Environmental Life Sciences Engineering, Singapore 637551, Singapore.

3. The Center for Microbes, Development and Health, Key Laboratory for Microbiota-Host Interactions, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

4. Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, SW72AZ London, UK.

5. Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117557, Singapore.

6. Duke-NUS Medical School, Singapore 169857, Singapore.

7. National Heart Research Institute, Singapore 169609, Singapore.

8. Penningtion Biomedical Research Center, Baton Rouge, LA 70808, USA.

9. Australian National Phenome Center, Murdoch University Perth, Perth, Western Australia, WA6150 Australia.

10. UK Dementia Research Institute at Imperial College London, Burlington Danes Building, Hammersmith Hospital, London, W12 0NN, UK.

11. Department of Neurobiology, Care Sciences and Society, Karolinska Institute, SE 17 177 Stockholm, Sweden.

Abstract

Transplantation of the gut microbiota of old donor mice into young germ-free mice promotes neurogenesis and prolongevity gene expression signatures.

Funder

NIHR Clinical Research Network Thames Valley and South Midlands

National Medical Research Council, Ministry of Heath, Singapore

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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