Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition-Reference-Cited by-同舟云学术

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

Published:2019-05-29 Issue:494 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Habets Roger A.¹²^ORCID,de Bock Charles E.³⁴⁵^ORCID,Serneels Lutgarde¹²^ORCID,Lodewijckx Inge³⁴,Verbeke Delphine³⁴^ORCID,Nittner David⁶⁷^ORCID,Narlawar Rajeshwar¹²^ORCID,Demeyer Sofie³⁴^ORCID,Dooley James²⁸^ORCID,Liston Adrian²⁸^ORCID,Taghon Tom⁹¹⁰^ORCID,Cools Jan³⁴^ORCID,de Strooper Bart¹²¹¹^ORCID

Affiliation:

1. Department of Neurosciences, Leuven Institute for Neuroscience and Disease (LIND), KU Leuven, 3000 Leuven, Belgium.

2. VIB Center for Brain and Disease Research, VIB, 3000 Leuven, Belgium.

3. Center for Human Genetics, KU Leuven, 3000 Leuven, Belgium.

4. VIB Center for Cancer Biology, VIB, 3000 Leuven, Belgium.

5. Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW 2052, Australia.

6. Histopathology Expertise Center, VIB-KU Leuven Center for Cancer Biology, 3000 Leuven, Belgium.

7. Department of Oncology, KU Leuven, 3000 Leuven, Belgium.

8. Department of Microbiology and Immunology, KU Leuven, 3000 Leuven, Belgium.

9. Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.

10. Cancer Research Institute Ghent, 9000 Ghent, Belgium.

11. Dementia Research Institute, University College London, London WC1E 6BT, UK.

Abstract

Selective inhibition of γ-secretase complexes targets T-ALL without the dose-limiting side effects of complete γ-secretase inhibition.

Funder

Stand Up To Cancer

European Research Council

Vlaamse Overheid

Fonds Wetenschappelijk Onderzoek

KU Leuven

Vlaams Instituut voor Biotechnologie

Bax-Vanluffelen Chair for Alzheimer’s Disease

Leuven Universiteit Fonds

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference68 articles.

1. A fast growing spectrum of biological functions of γ-secretase in development and disease

2. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

3. Presenilin-dependent -secretase activity modulates thymocyte development

4. Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

5. Morphologic and functional effects of gamma secretase inhibition on splenic marginal zone B cells;de Vera Mudry M. C.;Int. J. Alzheimers Dis.,2012

Cited by 72 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recording γ-secretase activity in living mouse brains;2024-01-31

2. Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy;iScience;2024-01

3. The effects of HPV oncoproteins on host communication networks: Therapeutic connotations;Journal of Medical Virology;2023-12

4. Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors;European Journal of Medicinal Chemistry;2023-11

5. The γ-secretase substrate proteome and its role in cell signaling regulation;Molecular Cell;2023-11