Noninvasive 11 C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis-Reference-Cited by-同舟云学术

Noninvasive 11 C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis

Published:2018-12-05 Issue:470 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tucker Elizabeth W.¹²³⁴^ORCID,Guglieri-Lopez Beatriz⁵^ORCID,Ordonez Alvaro A.¹²⁶^ORCID,Ritchie Brittaney¹²³,Klunk Mariah H.¹²⁶,Sharma Richa¹²⁶,Chang Yong S.¹²⁶^ORCID,Sanchez-Bautista Julian¹²⁶,Frey Sarah¹⁷,Lodge Martin A.⁷,Rowe Steven P.⁷,Holt Daniel P.⁷,Gobburu Jogarao V. S.⁵,Peloquin Charles A.⁸,Mathews William B.⁷^ORCID,Dannals Robert F.⁷^ORCID,Pardo Carlos A.⁹^ORCID,Kannan Sujatha³,Ivaturi Vijay D.⁵^ORCID,Jain Sanjay K.¹²⁶⁷^ORCID

Affiliation:

1. Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2. Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

3. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

4. Division of Pediatric Critical Care, Johns Hopkins All Children’s Hospital, St. Petersburg, FL 33701, USA.

5. Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.

6. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

7. Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

8. Infectious Disease Pharmacokinetics Laboratory, Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.

9. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Abstract

PET reveals spatially heterogeneous rifampin brain penetration, which decreases rapidly with treatment during tuberculous meningitis.

Funder

National Institutes of Health

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Johns Hopkins All Children's Hospital Foundation Institutional Grant Program

'Stimulating and Advancing ACCM Research’ (StAAR) grant from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine