Harnessing regulatory T cells to establish immune tolerance-Reference-Cited by-同舟云学术

Harnessing regulatory T cells to establish immune tolerance

Published:2024-03-13 Issue:738 Volume:16 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ho Patrick¹^ORCID,Cahir-McFarland Ellen²^ORCID,Fontenot Jason D.³^ORCID,Lodie Tracey⁴^ORCID,Nada Adel⁵,Tang Qizhi¹⁶⁷⁸^ORCID,Turka Laurence A.⁹,Bluestone Jeffrey A.¹⁰^ORCID

Affiliation:

1. Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.

2. Abata Therapeutics, Boston, MA 02472, USA.

3. Sangamo Therapeutics, Brisbane, CA 94005, USA.

4. Quell Therapeutics, London W12 OBZ, UK.

5. GentiBio, Cambridge, MA 02140, USA.

6. Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

7. Gladstone Institute of Genomic Immunology, University of California San Francisco, San Francisco, CA 94143, USA.

8. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA.

9. Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.

10. Sonoma Biotherapeutics, South San Francisco, CA 09080, USA.

Abstract

Engineered regulatory T (T reg ) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T reg cell therapies in treating autoimmune and other inflammatory diseases.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/scitranslmed.adm8859

Reference54 articles.

1. Immunological Tolerance

2. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

3. An essential role for Scurfin in CD4+CD25+ T regulatory cells

4. Control of Regulatory T Cell Development by the Transcription Factor Foxp3

5. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

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