Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

Author:

Garg Abhishek D.1,Vandenberk Lien2,Koks Carolien2,Verschuere Tina3,Boon Louis4,Van Gool Stefaan W.2,Agostinis Patrizia1

Affiliation:

1. Cell Death Research and Therapy Laboratory, Department of Cellular and Molecular Medicine, Katholieke Universiteit (KU) Leuven, Leuven 3000, Belgium.

2. Laboratory of Pediatric Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven 3000, Belgium.

3. Department of Neurosciences, Research Group—Neuroanatomy and Neurosurgery, KU Leuven, Leuven 3000, Belgium.

4. EPIRUS Biopharmaceuticals Netherlands BV, 3584 Utrecht, Netherlands.

Abstract

Combining an immunogenic cell death inducer with dendritic cell immunotherapy treats high-grade glioma in a preclinical model.

Funder

FWO (Fonds Wetenschappelijk Onderzoek)

IWT (Innovatie door Wetenschap en Technologie)

FWO

KU Leuven

Olivia Hendrickx Research Fund

James E. Kearney Memorial Fund

Herman Memorial Research Fund

Belgian Brain Tumor Support

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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