PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation-Reference-Cited by-同舟云学术

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

Published:2016-12-14 Issue:369 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Anderson Gray R.¹,Wardell Suzanne E.¹,Cakir Merve¹²,Crawford Lorin¹³,Leeds Jim C.¹,Nussbaum Daniel P.¹⁴,Shankar Pallavi S.¹,Soderquist Ryan S.¹,Stein Elizabeth M.¹,Tingley Jennifer P.¹,Winter Peter S.¹⁵,Zieser-Misenheimer Elizabeth K.¹,Alley Holly M.¹,Yllanes Alexander¹,Haney Victoria¹,Blackwell Kimberly L.⁶,McCall Shannon J.⁷,McDonnell Donald P.¹,Wood Kris C.¹

Affiliation:

1. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.

2. Program in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA.

3. Department of Statistical Science, Duke University, Durham, NC 27708, USA.

4. Department of Surgery, Duke University, Durham, NC 27710, USA.

5. Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.

6. Department of Medicine/Oncology, Duke University, Durham, NC 27710, USA.

7. Department of Pathology, Duke University, Durham, NC 27710, USA.

Abstract

Inhibitors of BCL-X L , combined with inhibition of the mTOR/4E-BP axis, drive regressions of PIK3CA mutant breast tumors.

Funder

Duke University School of Medicine