An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke-Reference-Cited by-同舟云学术

An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke

Published:2021-06-09 Issue:597 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Fang Zongping¹^ORCID,Wu Di²^ORCID,Deng Jiao¹^ORCID,Yang Qianzi¹,Zhang Xijing¹,Chen Jian²,Wang Shiquan¹,Hu Sijun³,Hou Wugang¹,Ning Siming³,Ding Yi⁴^ORCID,Fan Zhongmin¹,Jiang Zhenhua¹,Kang Junjun⁵,Liu Yingying⁵^ORCID,Miao Jinlin⁶,Ji Xunming²^ORCID,Dong Hailong¹^ORCID,Xiong Lize¹⁷^ORCID

Affiliation:

1. Department of Anesthesiology and Perioperative Medicine and Department of Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China.

2. Department of neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Beijing Institute of Brain Disorders, Capital Medical University, Beijing 10053, China.

3. State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

4. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

5. Department of Neurobiology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

6. National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi’an, Shaanxi 710032, China.

7. Translational Research Institute of Brain and Brain-Like Intelligence and Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, Tongji University School of Medicine, Shanghai 200434, China.

Abstract

Tat-CIRP perturbed the function of MD2 and provided robust neuroprotection in cells, rodents, and gyrencephalic nonhuman primates.

Funder

Innovative Research Group Project of the National Natural Science Foundation of China

National Key Research and Development Program of China Stem Cell and Translational Research

the Major Program of National Natural Science Foundation of China

International Cooperation and Exchange of the National Natural Science Foundation of China

the National Natural Science Foundation of China Youth Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference62 articles.

1. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990–2010: findings from the Global Burden of Disease Study 2010

2. Global burden of postoperative death

3. Global Variation in the Relative Burden of Stroke and Ischemic Heart Disease

4. Effect of a Multifaceted Quality Improvement Intervention on Hospital Personnel Adherence to Performance Measures in Patients With Acute Ischemic Stroke in China

5. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

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